Research workbench

Engbf darpin fusion 4B H14

Analyse Engbf darpin fusion 4B H14 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6QEP
Type: protein
Length: 1,341 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pega domain-containing PROTEIN,ENGBF-darpin fusion 4B H14
UniProt: A0A374RF80
Ligands: MN
Pockets: 17 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 20% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pega domain-containing PROTEIN,ENGBF-darpin fusion 4B H14	protein	1341	20% helix, 30% strand	A0A374RF80

Ligands and binding sites

MN · Manganese (II) ion · metal · 4 copies · chains A
MPD · (4S)-2-methyl-2,4-pentanediol · additive · chains A
MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

17 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	184	0.81	0.96	49	empty
2	1066	0.75	0.78	79	empty
3	63	0.74	0.99	25	empty
4	98	0.56	0.85	19	empty
5	228	0.52	0.76	31	empty

Compared structures

6QEP · EngBF DARPin Fusion 4b H14 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A374RF80
Elsewhere: RCSB PDB 6QEP · PDBe 6QEP · UniProt A0A374RF80

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