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2-desoxiribosyltransferase from leishmania mexicana

Analyse 2-desoxiribosyltransferase from leishmania mexicana in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6QAI
Type: protein
Length: 305 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 2-deoxyribosyltransferase
UniProt: E9AWJ0
Pockets: 2 · best druggability 0.36

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	2-deoxyribosyltransferase	protein	155	41% helix, 16% strand	E9AWJ0
B	2-deoxyribosyltransferase	protein	150	40% helix, 17% strand	E9AWJ0

Ligands and binding sites

TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	102	0.36	0.75	23	empty
2	77	0.36	0.76	13	empty

Interfaces

1 interface between chains.

A–B · 1914 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 covalent (additive adduct).

Compared structures

6QAI · 2-desoxiribosyltransferase from Leishmania mexicana · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E9AWJ0
Elsewhere: RCSB PDB 6QAI · PDBe 6QAI · UniProt E9AWJ0

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