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Bovine neurophysin II complex with oxytocin

Analyse Bovine neurophysin II complex with oxytocin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1NPO
Type: protein
Length: 178 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neurophysin II; Oxytocin
UniProt: P01180

Structure

x-ray diffraction · 3 distinct chains · 18% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Neurophysin II	protein	81	16% helix, 36% strand	P01180
B, D	Oxytocin	protein	9	33% helix, 11% strand	—
C	Neurophysin II	protein	79	18% helix, 41% strand	P01180

Interfaces

3 interfaces between chains.

A–C · 555 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 434 Å² buried · 10 hydrogen bonds · protein-protein
C–D · 420 Å² buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 disulfide (disulfide).

Compared structures

1NPO · Bovine neurophysin II complex with oxytocin · the same entry in another collection · chain A against A, TM-score 1.00
P01180 · AlphaFold monomer V2.0 prediction for vasopressin-neurophysin 2-copeptin (P01180) · a predicted model of the same protein · chain C against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01180
Elsewhere: RCSB PDB 1NPO · PDBe 1NPO · UniProt P01180

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