Research workbench
Structure of the plant immune signaling node EDS1 (enhanced disease susceptibility 1) in complex with nanobody ENB21
Analyse Structure of the plant immune signaling node EDS1 (enhanced disease… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6Q6Z
- Type
- protein
- Length
- 731 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein EDS1L; EDS1-specific nanobody
- UniProt
- Q9XF23
- Pockets
- 12 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein EDS1L | protein | 615 | 61% helix, 9% strand | Q9XF23 |
| B | EDS1-specific nanobody | protein | 116 | 3% helix, 47% strand | — |
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 65 | 0.74 | 0.98 | 19 | empty |
| 2 | 739 | 0.72 | 0.78 | 74 | empty |
| 3 | 314 | 0.65 | 0.81 | 49 | empty |
| 4 | 72 | 0.60 | 0.89 | 21 | empty |
| 5 | 201 | 0.55 | 0.79 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 735 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6Q6Z · Structure of the plant immune signaling node EDS1 (enhanced disease susceptibility 1) in… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9XF23 · AlphaFold monomer V2.0 prediction for protein EDS1L (Q9XF23) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9XF23
- Elsewhere: RCSB PDB 6Q6Z · PDBe 6Q6Z · UniProt Q9XF23
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