Research workbench
1-cys siprx, a PRX6-family 1-cys peroxiredoxin of the thermoacidophilic archaeon sulfolobus islandicus
Analyse 1-cys siprx, a PRX6-family 1-cys peroxiredoxin of the thermoacidophilic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6Q5V
- Type
- protein
- Length
- 2,080 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peroxiredoxin
- EC
- 1.11.1.15
- UniProt
- F0NEA3
- Pockets
- 18 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J | Peroxiredoxin (EC 1.11.1.15) | protein | 208 | 28% helix, 24% strand | F0NEA3 |
Pockets
18 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 421 | 0.65 | 0.78 | 50 | empty |
| 2 | 410 | 0.65 | 0.78 | 47 | empty |
| 3 | 362 | 0.65 | 0.80 | 41 | empty |
| 4 | 391 | 0.64 | 0.78 | 47 | empty |
| 5 | 385 | 0.64 | 0.79 | 42 | empty |
Interfaces
20 interfaces between chains.
- I–J · 2469 Ų buried · 42 hydrogen bonds · protein-protein
- E–F · 2462 Ų buried · 40 hydrogen bonds · protein-protein
- C–D · 2457 Ų buried · 40 hydrogen bonds · protein-protein
- G–H · 2453 Ų buried · 39 hydrogen bonds · protein-protein
- A–B · 2453 Ų buried · 38 hydrogen bonds · protein-protein
Compared structures
- 6Q5V · 1-Cys SiPrx, a Prx6-family 1-Cys peroxiredoxin of the thermoacidophilic archaeon… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F0NEA3
- Elsewhere: RCSB PDB 6Q5V · PDBe 6Q5V · UniProt F0NEA3
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