Research workbench
Structure of mpt-2, a GDP-man-dependent mannosyltransferase from leishmania mexicana
Analyse Structure of mpt-2, a GDP-man-dependent mannosyltransferase from leishmania… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6Q4X
- Type
- protein
- Length
- 627 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized protein
- UniProt
- E9AND8
- Ligands
- NA
- Pockets
- 8 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uncharacterized protein | protein | 317 | 9% helix, 50% strand | E9AND8 |
| B | Uncharacterized protein | protein | 310 | 9% helix, 52% strand | E9AND8 |
Ligands and binding sites
- NA · Sodium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 141 | 0.73 | 0.92 | 31 | empty |
| 2 | 132 | 0.72 | 0.92 | 30 | empty |
| 3 | 344 | 0.61 | 0.78 | 39 | empty |
| 4 | 238 | 0.52 | 0.76 | 28 | empty |
| 5 | 142 | 0.49 | 0.78 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 1354 Ų buried · 41 hydrogen bonds · protein-protein
Compared structures
- 6Q4X · Structure of MPT-2, a GDP-Man-dependent mannosyltransferase from Leishmania mexicana · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E9AND8
- Elsewhere: RCSB PDB 6Q4X · PDBe 6Q4X · UniProt E9AND8
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