Research workbench
Crystal structure of human na-22 Fab
Analyse Crystal structure of human na-22 Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PZH
- Type
- protein
- Length
- 872 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Na-22 Fab light chain; Na-22 Fab heavy chain
- Pockets
- 7 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 7% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Na-22 Fab light chain | protein | 213 | 6% helix, 50% strand | — |
| H, B | Na-22 Fab heavy chain | protein | 222 | 8% helix, 50% strand | — |
| A | Na-22 Fab light chain | protein | 215 | 6% helix, 50% strand | — |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 676 | 0.67 | 0.76 | 66 | empty |
| 2 | 517 | 0.67 | 0.78 | 74 | empty |
| 3 | 402 | 0.58 | 0.75 | 41 | empty |
| 4 | 302 | 0.58 | 0.77 | 51 | empty |
| 5 | 189 | 0.45 | 0.75 | 26 | empty |
Interfaces
5 interfaces between chains.
- A–B · 1950 Ų buried · 13 hydrogen bonds · protein-protein
- L–H · 1931 Ų buried · 9 hydrogen bonds · protein-protein
- L–A · 109 Ų buried · 0 hydrogen bonds · protein-protein
- H–A · 104 Ų buried · 0 hydrogen bonds · protein-protein
- L–B · 73 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 6PZH · Crystal structure of human NA-22 Fab · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6PZH · PDBe 6PZH
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