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Crystal structure of folp (dihydropteroate synthase) from colstridium difficile in the presence of pteroic acid
Analyse Crystal structure of folp (dihydropteroate synthase) from colstridium difficile… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PZ2
- Type
- protein
- Length
- 263 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dihydropteroate synthase
- EC
- 2.5.1.15
- UniProt
- A0A160WS51
- Ligands
- PT1, SO4
- Pockets
- 4 · best druggability 0.61
Structure
x-ray diffraction · 1 distinct chain · 48% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dihydropteroate synthase (EC 2.5.1.15) | protein | 263 | 48% helix, 14% strand | A0A160WS51 |
Ligands and binding sites
- PT1 · Pteroic acid · ligand · chains A
- SO4 · Sulfate ion · ion · 9 copies · chains A
- NHE · 2-[N-cyclohexylamino]ethane sulfonic acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 226 | 0.61 | 0.81 | 38 | SO4, PT1 |
| 2 | 89 | 0.36 | 0.75 | 17 | SO4 |
| 3 | 61 | 0.33 | 0.76 | 16 | NHE |
| 4 | 67 | 0.33 | 0.75 | 15 | empty |
Compared structures
- 6PZ2 · Crystal Structure of FolP (dihydropteroate synthase) from Colstridium difficile in the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A160WS51
- Elsewhere: RCSB PDB 6PZ2 · PDBe 6PZ2 · UniProt A0A160WS51
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