Research workbench
Crystal structure of mouse serum amyloid A3 (SAA3) in the trimeric form
Analyse Crystal structure of mouse serum amyloid A3 (SAA3) in the trimeric form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PXZ
- Type
- protein
- Length
- 305 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Serum amyloid a-3 protein
- UniProt
- P04918
- Pockets
- 4 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 76% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Serum amyloid a-3 protein | protein | 99 | 76% helix, 0% strand | P04918 |
| B, C | Serum amyloid a-3 protein | protein | 103 | 76% helix, 0% strand | P04918 |
Ligands and binding sites
- DMU · Decyl-beta-D-maltopyranoside · additive · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 945 | 0.80 | 0.82 | 65 | DMU |
| 2 | 87 | 0.41 | 0.78 | 16 | empty |
| 3 | 123 | 0.40 | 0.75 | 15 | empty |
| 4 | 54 | 0.30 | 0.76 | 10 | empty |
Interfaces
3 interfaces between chains.
- A–B · 391 Ų buried · 0 hydrogen bonds · protein-protein
- A–C · 367 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 330 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 6PXZ · Crystal Structure of mouse Serum Amyloid A3 (SAA3) in the trimeric form · the same entry in another collection · chain A against A, TM-score 1.00
- P04918 · AlphaFold monomer V2.0 prediction for serum amyloid a-3 protein (P04918) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P04918
- Elsewhere: RCSB PDB 6PXZ · PDBe 6PXZ · UniProt P04918
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.