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Crystal structure of the complex between periplasmic domains of antiholin ri and holin T from T4 phage, in P21
Analyse Crystal structure of the complex between periplasmic domains of antiholin ri… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PXE
- Type
- protein
- Length
- 889 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antiholin; Holin
- UniProt
- P13304, A0A2U8QQK7
- Pockets
- 11 · best druggability 0.75
Structure
x-ray diffraction · 6 distinct chains · 40% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R, A, C | Antiholin | protein | 72 | 72% helix, 1% strand | P13304 |
| T | Holin | protein | 147 | 32% helix, 27% strand | A0A2U8QQK7 |
| B | Holin | protein | 145 | 31% helix, 28% strand | A0A2U8QQK7 |
| D | Holin | protein | 154 | 32% helix, 26% strand | A0A2U8QQK7 |
| E | Antiholin | protein | 70 | 73% helix, 1% strand | P13304 |
| F | Holin | protein | 157 | 36% helix, 25% strand | A0A2U8QQK7 |
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 930 | 0.75 | 0.78 | 71 | empty |
| 2 | 361 | 0.73 | 0.84 | 49 | empty |
| 3 | 609 | 0.69 | 0.78 | 78 | empty |
| 4 | 181 | 0.63 | 0.84 | 21 | empty |
| 5 | 158 | 0.61 | 0.84 | 21 | empty |
Interfaces
15 interfaces between chains.
- R–T · 730 Ų buried · 10 hydrogen bonds · protein-protein
- E–F · 729 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 716 Ų buried · 12 hydrogen bonds · protein-protein
- A–B · 696 Ų buried · 10 hydrogen bonds · protein-protein
- C–F · 621 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 6PXE · Crystal structure of the complex between periplasmic domains of antiholin RI and holin T… · the same entry in another collection · chain F against F, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13304
- Every structure of UniProt A0A2U8QQK7
- Elsewhere: RCSB PDB 6PXE · PDBe 6PXE · UniProt P13304 · UniProt A0A2U8QQK7
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