Research workbench
Crystal structure of the complex between periplasmic domains of antiholin ri and holin T from T4 phage, in H32
Analyse Crystal structure of the complex between periplasmic domains of antiholin ri… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PX4
- Type
- protein
- Length
- 427 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antiholin; Holin
- UniProt
- I7AU04, A0A2U8QQK7
- Pockets
- 8 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 38% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R, A | Antiholin | protein | 72 | 71% helix, 4% strand | I7AU04 |
| T | Holin | protein | 142 | 29% helix, 28% strand | A0A2U8QQK7 |
| B | Holin | protein | 141 | 30% helix, 28% strand | A0A2U8QQK7 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 167 | 0.67 | 0.87 | 23 | empty |
| 2 | 175 | 0.63 | 0.84 | 22 | empty |
| 3 | 84 | 0.44 | 0.80 | 22 | empty |
| 4 | 114 | 0.43 | 0.77 | 23 | empty |
| 5 | 98 | 0.39 | 0.76 | 20 | empty |
Interfaces
6 interfaces between chains.
- R–T · 714 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 701 Ų buried · 8 hydrogen bonds · protein-protein
- R–B · 591 Ų buried · 12 hydrogen bonds · protein-protein
- T–A · 591 Ų buried · 13 hydrogen bonds · protein-protein
- T–B · 204 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6PX4 · Crystal structure of the complex between periplasmic domains of antiholin RI and holin T… · the same entry in another collection · chain R against R, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt I7AU04
- Every structure of UniProt A0A2U8QQK7
- Elsewhere: RCSB PDB 6PX4 · PDBe 6PX4 · UniProt I7AU04 · UniProt A0A2U8QQK7
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