Research workbench
Structural evidence for a pH-sensitive di-lysine trigger in the hen ovotransferrin N-lobe: implications for transferrin iron release
Analyse Structural evidence for a pH-sensitive di-lysine trigger in the hen… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1NNT
- Type
- protein
- Length
- 328 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ovotransferrin
- UniProt
- P02789
- Ligands
- FE, CO3
- Pockets
- 5 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ovotransferrin | protein | 328 | 31% helix, 21% strand | P02789 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 239 | 0.80 | 0.93 | 34 | empty |
| 2 | 121 | 0.49 | 0.80 | 20 | empty |
| 3 | 94 | 0.37 | 0.75 | 20 | empty |
| 4 | 73 | 0.31 | 0.74 | 14 | empty |
| 5 | 63 | 0.29 | 0.73 | 16 | empty |
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1NNT · Structural evidence for a pH-sensitive di-lysine trigger in the hen ovotransferrin… · the same entry in another collection · chain A against A, TM-score 1.00
- P02789 · AlphaFold monomer V2.0 prediction for ovotransferrin (P02789) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02789
- Elsewhere: RCSB PDB 1NNT · PDBe 1NNT · UniProt P02789
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.