Research workbench
Structural genomics, RPIB/ALSB
Analyse Structural genomics, RPIB/ALSB in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1NN4
- Type
- protein
- Length
- 635 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribose 5-phosphate isomerase B
- EC
- 5.3.1.6
- UniProt
- P37351
- Pockets
- 8 · best druggability 0.74
Structure
x-ray diffraction · 3 distinct chains · 44% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Ribose 5-phosphate isomerase B (EC 5.3.1.6) | protein | 159 | 43% helix, 18% strand | P37351 |
| B | Ribose 5-phosphate isomerase B (EC 5.3.1.6) | protein | 158 | 45% helix, 18% strand | P37351 |
| D | Ribose 5-phosphate isomerase B (EC 5.3.1.6) | protein | 159 | 45% helix, 18% strand | P37351 |
Pockets
8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 62 | 0.74 | 0.99 | 20 | empty |
| 2 | 347 | 0.62 | 0.79 | 37 | empty |
| 3 | 324 | 0.62 | 0.79 | 39 | empty |
| 4 | 250 | 0.59 | 0.79 | 35 | empty |
| 5 | 121 | 0.57 | 0.84 | 19 | empty |
Interfaces
6 interfaces between chains.
- B–C · 1547 Ų buried · 14 hydrogen bonds · protein-protein
- A–D · 1539 Ų buried · 16 hydrogen bonds · protein-protein
- A–B · 1177 Ų buried · 25 hydrogen bonds · protein-protein
- C–D · 1175 Ų buried · 25 hydrogen bonds · protein-protein
- A–C · 331 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37351
- Elsewhere: RCSB PDB 1NN4 · PDBe 1NN4 · UniProt P37351
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