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Time-resolved structural snapshot of proteolysis by glpg inside the membrane

Analyse Time-resolved structural snapshot of proteolysis by glpg inside the membrane in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6PJQ
Type: protein
Length: 178 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Rhomboid protease glpg; Peptide aldehyde inhibitor
EC: 3.4.21.105
UniProt: A0A0J2E248
Pockets: 1 · best druggability 0.32

Structure

x-ray diffraction · 2 distinct chains · 76% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Rhomboid protease glpg (EC 3.4.21.105)	protein	173	79% helix, 2% strand	A0A0J2E248
B	Peptide aldehyde inhibitor	protein	5	0% helix, 40% strand	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	66	0.32	0.74	18	empty

Interfaces

1 interface between chains.

A–B · 547 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

6PJQ · Time-resolved structural snapshot of proteolysis by GlpG inside the membrane · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0J2E248
Elsewhere: RCSB PDB 6PJQ · PDBe 6PJQ · UniProt A0A0J2E248

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