Research workbench

Predicted germline variant of human transmission blocking antibody 2544

Analyse Predicted germline variant of human transmission blocking antibody 2544 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6PHG
Type: protein
Length: 427 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Germline 2544 antibody Fab, heavy chain; Germline 2544 antibody Fab, light chain
Pockets: 3 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 52% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Germline 2544 antibody Fab, heavy chain	protein	224	8% helix, 54% strand	—
B	Germline 2544 antibody Fab, light chain	protein	203	6% helix, 50% strand	—

Ligands and binding sites

GOL · Glycerol · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	542	0.62	0.75	54	empty
2	207	0.47	0.75	34	empty
3	108	0.41	0.76	23	empty

Interfaces

1 interface between chains.

A–B · 1979 Å² buried · 21 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6PHG · Predicted germline variant of human transmission blocking antibody 2544 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6PHG · PDBe 6PHG

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