Research workbench
Staphylococcus aureus dihydrofolate reductase in complex with NADPH and UCP1232
Analyse Staphylococcus aureus dihydrofolate reductase in complex with NADPH and UCP1232 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6PBO
- Type
- protein
- Length
- 157 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dihydrofolate reductase
- EC
- 1.5.1.3
- UniProt
- P0A017
- Ligands
- O71, XNP, NAP
- Pockets
- 1 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 18% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| X | Dihydrofolate reductase (EC 1.5.1.3) | protein | 157 | 18% helix, 37% strand | P0A017 |
Ligands and binding sites
- O71 · (4-{6-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-2H-1,3-benzodioxol-4-yl}phenyl)acetic acid · ligand · chains X
- XNP · Tricyclic NADPH · ligand · chains X
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains X
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 376 | 0.69 | 0.81 | 37 | O71, XNP, NAP |
Compared structures
- 6PBO · Staphylococcus aureus Dihydrofolate reductase in complex with NADPH and UCP1232 · the same entry in another collection · chain X against X, TM-score 1.00
- P0A017 · AlphaFold monomer V2.0 prediction for dihydrofolate reductase (P0A017) · a predicted model of the same protein · chain X against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A017
- Elsewhere: RCSB PDB 6PBO · PDBe 6PBO · UniProt P0A017
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