Research workbench
Crystal structure of fowlpox virus resolvase and substrate holliday junction DNA complex
Analyse Crystal structure of fowlpox virus resolvase and substrate holliday junction… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6P7B
- Type
- protein + DNA
- Length
- 649 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Holliday junction resolvase; DNA (29-mer)
- UniProt
- A0A385H9X4
- Pockets
- 12 · best druggability 0.78
Structure
x-ray diffraction · 5 distinct chains · 38% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Holliday junction resolvase | protein | 149 | 41% helix, 21% strand | A0A385H9X4 |
| B, C | Holliday junction resolvase | protein | 148 | 37% helix, 22% strand | A0A385H9X4 |
| D | Holliday junction resolvase | protein | 146 | 37% helix, 22% strand | A0A385H9X4 |
| E | DNA (29-mer) | dna | 29 | — | — |
| F | DNA (29-mer) | dna | 29 | — | — |
Pockets
12 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1008 | 0.78 | 0.80 | 65 | empty |
| 2 | 170 | 0.62 | 0.83 | 25 | empty |
| 3 | 131 | 0.54 | 0.81 | 22 | empty |
| 4 | 311 | 0.51 | 0.74 | 31 | empty |
| 5 | 116 | 0.49 | 0.80 | 24 | empty |
Interfaces
10 interfaces between chains.
- E–F · 900 Ų buried · 54 hydrogen bonds · nucleic-nucleic
- A–C · 697 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 640 Ų buried · 1 hydrogen bond · protein-protein
- B–F · 465 Ų buried · 5 hydrogen bonds · protein-nucleic
- B–E · 343 Ų buried · 1 hydrogen bond · protein-nucleic
Compared structures
- 6P7B · Crystal structure of Fowlpox virus resolvase and substrate Holliday junction DNA complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A385H9X4
- Elsewhere: RCSB PDB 6P7B · PDBe 6P7B · UniProt A0A385H9X4
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