Research workbench
Crystal structure of anti-il-7RALPHA 4A10 Fab
Analyse Crystal structure of anti-il-7RALPHA 4A10 Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6P4Y
- Type
- protein
- Length
- 431 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 4A10 Fab heavy chain; 4A10 Fab light chain
- Pockets
- 4 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | 4A10 Fab heavy chain | protein | 219 | 8% helix, 52% strand | — |
| L | 4A10 Fab light chain | protein | 212 | 6% helix, 52% strand | — |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 312 | 0.51 | 0.74 | 43 | empty |
| 2 | 122 | 0.41 | 0.75 | 25 | empty |
| 3 | 86 | 0.35 | 0.75 | 20 | empty |
| 4 | 65 | 0.32 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- H–L · 1856 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6P4Y · Crystal Structure of anti-IL-7Ralpha 4A10 Fab · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6P4Y · PDBe 6P4Y
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