Research workbench
Bile salts alter the mouse norovirus capsid conformation; possible implications for cell attachment and immune evasion.
Analyse Bile salts alter the mouse norovirus capsid conformation; possible implications… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6P4L
- Type
- protein
- Length
- 601 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Capsid protein
- UniProt
- Q2V8W4
- Pockets
- 4 · best druggability 0.48
Structure
electron microscopy · 3 distinct chains · 8% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Capsid protein | protein | 203 | 10% helix, 34% strand | Q2V8W4 |
| B | Capsid protein | protein | 205 | 6% helix, 30% strand | Q2V8W4 |
| C | Capsid protein | protein | 193 | 9% helix, 35% strand | Q2V8W4 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 162 | 0.48 | 0.77 | 29 | empty |
| 2 | 64 | 0.41 | 0.81 | 18 | empty |
| 3 | 85 | 0.36 | 0.76 | 19 | empty |
| 4 | 68 | 0.30 | 0.74 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–C · 865 Ų buried · 7 hydrogen bonds · protein-protein
- A–B · 810 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 805 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 6P4L · Bile salts alter the mouse norovirus capsid conformation; possible implications for cell… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2V8W4
- Elsewhere: RCSB PDB 6P4L · PDBe 6P4L · UniProt Q2V8W4
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