Research workbench
HYHEL10 Fab carrying four heavy chain mutations (HYHEL10-4X): L4F, Y33H, S56N, and Y58F
Analyse HYHEL10 Fab carrying four heavy chain mutations (HYHEL10-4X): L4F, Y33H, S56N… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6P4C
- Type
- protein
- Length
- 420 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HYHEL10 Fab light chain; HYHEL10 Fab heavy chain
- UniProt
- A0A0E4B213
- Ligands
- CL
- Pockets
- 3 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | HYHEL10 Fab light chain | protein | 207 | 6% helix, 52% strand | A0A0E4B213 |
| H | HYHEL10 Fab heavy chain | protein | 213 | 8% helix, 52% strand | — |
Ligands and binding sites
- CL · Chloride ion · ion · 7 copies · chains L, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 428 | 0.57 | 0.74 | 52 | CL |
| 2 | 280 | 0.57 | 0.77 | 41 | empty |
| 3 | 51 | 0.25 | 0.73 | 16 | empty |
Interfaces
1 interface between chains.
- L–H · 1703 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6P4C · HyHEL10 Fab carrying four heavy chain mutations (HyHEL10-4x): L4F, Y33H, S56N, and Y58F · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0E4B213
- Elsewhere: RCSB PDB 6P4C · PDBe 6P4C · UniProt A0A0E4B213
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