Research workbench
Crystal structure of the 65-kilodalton amino-terminal fragment of DNA topoisomerase I from streptococcus mutans
Analyse Crystal structure of the 65-kilodalton amino-terminal fragment of DNA… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6OZW
- Type
- protein
- Length
- 538 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA topoisomerase 1
- EC
- 5.6.2.2
- UniProt
- Q8DUD3
- Ligands
- MG
- Pockets
- 1 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA topoisomerase 1 (EC 5.6.2.2) | protein | 538 | 46% helix, 22% strand | Q8DUD3 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 749 | 0.70 | 0.77 | 68 | MG, FMT |
Compared structures
- 6OZW · Crystal structure of the 65-kilodalton amino-terminal fragment of DNA topoisomerase I… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8DUD3
- Elsewhere: RCSB PDB 6OZW · PDBe 6OZW · UniProt Q8DUD3
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