Research workbench
Crystal structure of human claudin-9 in complex with clostridium perfringens entertoxin C-terminal domain in open form
Analyse Crystal structure of human claudin-9 in complex with clostridium perfringens… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6OV3
- Type
- protein
- Length
- 302 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Claudin-9; Heat-labile enterotoxin B chain
- UniProt
- O95484, P01558
- Pockets
- 2 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Claudin-9 | protein | 179 | 53% helix, 13% strand | O95484 |
| B | Heat-labile enterotoxin B chain | protein | 123 | 6% helix, 53% strand | P01558 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 610 | 0.73 | 0.81 | 51 | empty |
| 2 | 96 | 0.46 | 0.80 | 29 | empty |
Interfaces
1 interface between chains.
- A–B · 1177 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6OV3 · Crystal structure of human claudin-9 in complex with Clostridium perfringens entertoxin… · the same entry in another collection · chain A against A, TM-score 1.00
- P01558 · AlphaFold monomer V2.0 prediction for heat-labile enterotoxin B chain (P01558) · a predicted model of the same protein · chain B against A, TM-score 0.93
- O95484 · AlphaFold monomer V2.0 prediction for claudin-9 (O95484) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95484
- Every structure of UniProt P01558
- Elsewhere: RCSB PDB 6OV3 · PDBe 6OV3 · UniProt O95484 · UniProt P01558
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