Research workbench
Crystal structure of CSM6 in complex with A4>P by soaking A4>P into CSM6
Analyse Crystal structure of CSM6 in complex with A4>P by soaking A4>P into CSM6 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6OV0
- Type
- protein + RNA
- Length
- 1,742 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uncharacterized protein; RNA (5'-R(*AP*AP*AP*(A23))-3')
- UniProt
- B6YWC3
- Pockets
- 20 · best druggability 0.86
Structure
x-ray diffraction · 4 distinct chains · 47% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Uncharacterized protein | protein | 433 | 47% helix, 21% strand | B6YWC3 |
| B, D | Uncharacterized protein | protein | 432 | 47% helix, 20% strand | B6YWC3 |
| E, H | RNA (5'-R(*AP*AP*AP*(A23))-3') | rna | 4 | — | — |
| F, G | RNA (5'-R(*AP*AP*AP*(A23))-3') | rna | 2 | — | — |
Pockets
20 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1171 | 0.86 | 0.87 | 79 | empty |
| 2 | 1178 | 0.86 | 0.87 | 80 | empty |
| 3 | 524 | 0.63 | 0.76 | 49 | empty |
| 4 | 278 | 0.54 | 0.76 | 25 | empty |
| 5 | 255 | 0.53 | 0.76 | 19 | empty |
Interfaces
11 interfaces between chains.
- C–D · 2358 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 2354 Ų buried · 18 hydrogen bonds · protein-protein
- B–D · 523 Ų buried · 3 hydrogen bonds · protein-protein
- D–H · 511 Ų buried · 12 hydrogen bonds · protein-nucleic
- A–E · 501 Ų buried · 13 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 4 modified (nucleotide modification).
Compared structures
- 6OV0 · Crystal structure of Csm6 in complex with A4>p by soaking A4>p into Csm6 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B6YWC3
- Elsewhere: RCSB PDB 6OV0 · PDBe 6OV0 · UniProt B6YWC3
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