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Crystal structure of the D478N variant of the myocilin olfactomedin domain

Analyse Crystal structure of the D478N variant of the myocilin olfactomedin domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6OU2
Type: protein
Length: 249 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myocilin
UniProt: Q99972
Ligands: NA
Pockets: 2 · best druggability 0.49

Structure

x-ray diffraction · 1 distinct chain · 3% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Myocilin	protein	249	3% helix, 49% strand	Q99972

Ligands and binding sites

NA · Sodium ion · metal · chains A
GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	93	0.49	0.82	24	empty
2	57	0.41	0.81	16	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

6OU2 · Crystal Structure of the D478N Variant of the Myocilin Olfactomedin Domain · the same entry in another collection · chain A against A, TM-score 1.00
Q99972 · AlphaFold monomer V2.0 prediction for myocilin (Q99972) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99972
Elsewhere: RCSB PDB 6OU2 · PDBe 6OU2 · UniProt Q99972

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