Research workbench
Crystal structure of an apo transferrin-receptor-binding cystine-dense peptide
Analyse Crystal structure of an apo transferrin-receptor-binding cystine-dense peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6OKE
- Type
- protein
- Length
- 151 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transferrin-receptor binding peptide
- Pockets
- 2 · best druggability 0.38
Structure
x-ray diffraction · 3 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C, B | Transferrin-receptor binding peptide | protein | 38 | 79% helix, 0% strand | — |
| A | Transferrin-receptor binding peptide | protein | 32 | 78% helix, 0% strand | — |
| D | Transferrin-receptor binding peptide | protein | 43 | 84% helix, 0% strand | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.38 | 0.78 | 15 | empty |
| 2 | 92 | 0.35 | 0.75 | 17 | empty |
Interfaces
6 interfaces between chains.
- C–D · 608 Ų buried · 4 hydrogen bonds · protein-protein
- A–B · 405 Ų buried · 2 hydrogen bonds · protein-protein
- B–D · 342 Ų buried · 3 hydrogen bonds · protein-protein
- C–A · 204 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 202 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 11 disulfide (disulfide).
Compared structures
- 6OKE · Crystal structure of an apo Transferrin-Receptor-Binding cystine-dense peptide · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6OKE · PDBe 6OKE
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