Research workbench
Crystal structure of myst acetyltransferase domain in complex with inhibitor 62
Analyse Crystal structure of myst acetyltransferase domain in complex with inhibitor 62 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6OIR
- Type
- protein
- Length
- 272 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone acetyltransferase KAT8
- EC
- 2.3.1.48
- UniProt
- Q9H7Z6
- Ligands
- MNJ, ZN
- Pockets
- 3 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone acetyltransferase KAT8 (EC 2.3.1.48) | protein | 272 | 36% helix, 24% strand | Q9H7Z6 |
Ligands and binding sites
- MNJ · 4-fluoro-N'-(phenylsulfonyl)[1,1'-biphenyl]-3-carbohydrazide · ligand · chains A
- ZN · Zinc ion · metal · chains A
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 358 | 0.72 | 0.83 | 46 | MNJ, GOL |
| 2 | 107 | 0.40 | 0.76 | 15 | empty |
| 3 | 99 | 0.38 | 0.76 | 25 | empty |
Modifications
Observed in the structure: 1 modified (acetylation).
Compared structures
- 6OIR · Crystal structure of MYST acetyltransferase domain in complex with inhibitor 62 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9H7Z6 · AlphaFold monomer V2.0 prediction for histone acetyltransferase KAT8 (Q9H7Z6) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H7Z6
- Elsewhere: RCSB PDB 6OIR · PDBe 6OIR · UniProt Q9H7Z6
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