Research workbench
Crystal structure of (E)-biformene synthase lrdc from streptomyces sp. strain K155 in the dimeric form
Analyse Crystal structure of (E)-biformene synthase lrdc from streptomyces sp. strain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6OH8
- Type
- protein
- Length
- 611 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Labdane-related diterpene synthase
- EC
- 4.2.3.193
- UniProt
- A0A158RFK9
- Pockets
- 7 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Labdane-related diterpene synthase (EC 4.2.3.193) | protein | 306 | 72% helix, 0% strand | A0A158RFK9 |
| B | Labdane-related diterpene synthase (EC 4.2.3.193) | protein | 305 | 72% helix, 0% strand | A0A158RFK9 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 492 | 0.78 | 0.85 | 44 | empty |
| 2 | 503 | 0.76 | 0.84 | 64 | PEG |
| 3 | 665 | 0.75 | 0.81 | 59 | GOL |
| 4 | 590 | 0.73 | 0.81 | 59 | PEG |
| 5 | 62 | 0.41 | 0.81 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 1382 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 6OH8 · Crystal structure of (E)-biformene synthase LrdC from Streptomyces sp. strain K155 in the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A158RFK9
- Elsewhere: RCSB PDB 6OH8 · PDBe 6OH8 · UniProt A0A158RFK9
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