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In vitro polymerized prgi V67A filaments

Analyse In vitro polymerized prgi V67A filaments in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6OFG
Type: protein
Length: 1,404 residues
Chains: 18
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein prgi
UniProt: A0A0H3NF82
Pockets: 20 · best druggability 0.70

Structure

electron microscopy · 1 distinct chain · 83% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
P, Q, R, K, L, M, N, O, F, G, H, I, J, A, B, C, D, E	Protein prgi	protein	78	83% helix, 0% strand	A0A0H3NF82

Pockets

20 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1020	0.70	0.75	132	empty
2	312	0.55	0.75	38	empty
3	278	0.53	0.75	39	empty
4	257	0.51	0.75	28	empty
5	205	0.49	0.75	24	empty

Interfaces

49 interfaces between chains.

K–E · 901 Å² buried · 12 hydrogen bonds · protein-protein
J–D · 890 Å² buried · 15 hydrogen bonds · protein-protein
M–G · 889 Å² buried · 15 hydrogen bonds · protein-protein
O–I · 888 Å² buried · 15 hydrogen bonds · protein-protein
Q–F · 888 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

6OFG · In vitro polymerized PrgI V67A filaments · the same entry in another collection · chain P against P, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0H3NF82
Elsewhere: RCSB PDB 6OFG · PDBe 6OFG · UniProt A0A0H3NF82

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