Research workbench
Structure of the ganjam virus otu bound to sheep ISG15
Analyse Structure of the ganjam virus otu bound to sheep ISG15 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6OAT
- Type
- protein
- Length
- 624 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-dependent RNA polymerase; Interferon stimulated gene 17
- UniProt
- A0A191KWA2, Q9GKP4
- Ligands
- AYE
- Pockets
- 8 · best druggability 0.54
Structure
x-ray diffraction · 3 distinct chains · 24% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | RNA-dependent RNA polymerase | protein | 158 | 30% helix, 24% strand | A0A191KWA2 |
| B | Interferon stimulated gene 17 | protein | 155 | 19% helix, 30% strand | Q9GKP4 |
| D | Interferon stimulated gene 17 | protein | 153 | 22% helix, 31% strand | Q9GKP4 |
Ligands and binding sites
- AYE · prop-2-en-1-amine · ligand · 2 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.54 | 0.88 | 16 | empty |
| 2 | 187 | 0.53 | 0.78 | 29 | empty |
| 3 | 107 | 0.50 | 0.81 | 25 | empty |
| 4 | 222 | 0.48 | 0.75 | 25 | empty |
| 5 | 194 | 0.47 | 0.75 | 43 | empty |
Interfaces
3 interfaces between chains.
- C–D · 1031 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 1002 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 477 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 4 covalent (covalent ligand).
Compared structures
- 6OAT · Structure of the Ganjam virus OTU bound to sheep ISG15 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A191KWA2
- Every structure of UniProt Q9GKP4
- Elsewhere: RCSB PDB 6OAT · PDBe 6OAT · UniProt A0A191KWA2 · UniProt Q9GKP4
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