Research workbench
Anti-CD28XCD3 codv Fab
Analyse Anti-CD28XCD3 codv Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6O89
- Type
- protein
- Length
- 680 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anti-CD28XCD3 codv-Fab heavy chain; Anti-CD28XCD3 codv-Fab light chain
- Pockets
- 9 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | Anti-CD28XCD3 codv-Fab heavy chain | protein | 342 | 11% helix, 49% strand | — |
| L | Anti-CD28XCD3 codv-Fab light chain | protein | 338 | 5% helix, 49% strand | — |
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 657 | 0.65 | 0.75 | 69 | empty |
| 2 | 118 | 0.57 | 0.84 | 27 | empty |
| 3 | 57 | 0.49 | 0.86 | 20 | empty |
| 4 | 193 | 0.49 | 0.76 | 34 | empty |
| 5 | 105 | 0.38 | 0.75 | 22 | empty |
Interfaces
1 interface between chains.
- H–L · 2762 Ų buried · 34 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 disulfide (disulfide).
Compared structures
- 6O89 · Anti-CD28xCD3 CODV Fab · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6O89 · PDBe 6O89
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