Research workbench
Melatonin biosynthesis: the structure of serotonin N- acetyltransferase at 2.5 a resolution suggests a catalytic mechanism
Analyse Melatonin biosynthesis: the structure of serotonin N- acetyltransferase at 2.5… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1B6B
- Type
- protein
- Length
- 324 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (arylalkylamine N-acetyltransferase)
- EC
- 2.3.1.87
- UniProt
- Q29495
- Pockets
- 5 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (arylalkylamine N-acetyltransferase) (EC 2.3.1.87) | protein | 168 | 26% helix, 30% strand | Q29495 |
| B | Protein (arylalkylamine N-acetyltransferase) (EC 2.3.1.87) | protein | 156 | 27% helix, 33% strand | Q29495 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 277 | 0.77 | 0.89 | 31 | empty |
| 2 | 232 | 0.55 | 0.77 | 35 | empty |
| 3 | 177 | 0.47 | 0.76 | 23 | empty |
| 4 | 50 | 0.27 | 0.75 | 15 | empty |
| 5 | 54 | 0.25 | 0.72 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 598 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1B6B · Melatonin biosynthesis: the structure of serotonin N-acetyltransferase at 2.5 a… · the same entry in another collection · chain A against A, TM-score 1.00
- Q29495 · AlphaFold monomer V2.0 prediction for serotonin N-acetyltransferase (Q29495) · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q29495
- Elsewhere: RCSB PDB 1B6B · PDBe 1B6B · UniProt Q29495
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.