Research workbench
Crystal structure of the saraf luminal domain cys-lock mutant monomer
Analyse Crystal structure of the saraf luminal domain cys-lock mutant monomer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6O2V
- Type
- protein
- Length
- 270 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Store-operated calcium entry-associated regulatory factor
- UniProt
- Q96BY9
- Pockets
- 2 · best druggability 0.45
Structure
x-ray diffraction · 1 distinct chain · 5% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Store-operated calcium entry-associated regulatory factor | protein | 135 | 5% helix, 44% strand | Q96BY9 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 72 | 0.45 | 0.82 | 21 | empty |
| 2 | 64 | 0.39 | 0.79 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 662 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 6O2V · Crystal structure of the SARAF luminal domain Cys-lock mutant monomer · the same entry in another collection · chain A against A, TM-score 1.00
- Q96BY9 · AlphaFold monomer V2.0 prediction for store-operated calcium entry- associated regulatory… · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96BY9
- Elsewhere: RCSB PDB 6O2V · PDBe 6O2V · UniProt Q96BY9
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