Research workbench
Crystal structure of the saraf luminal domain
Analyse Crystal structure of the saraf luminal domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6O2U
- Type
- protein
- Length
- 253 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Store-operated calcium entry-associated regulatory factor
- UniProt
- Q96BY9
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Store-operated calcium entry-associated regulatory factor | protein | 132 | 9% helix, 39% strand | Q96BY9 |
| B | Store-operated calcium entry-associated regulatory factor | protein | 121 | 10% helix, 38% strand | Q96BY9 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 507 | 0.63 | 0.76 | 64 | empty |
| 2 | 54 | 0.32 | 0.76 | 16 | empty |
| 3 | 63 | 0.29 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 127 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 6O2U · Crystal structure of the SARAF luminal domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q96BY9 · AlphaFold monomer V2.0 prediction for store-operated calcium entry- associated regulatory… · a predicted model of the same protein · chain B against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96BY9
- Elsewhere: RCSB PDB 6O2U · PDBe 6O2U · UniProt Q96BY9
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