Research workbench
Architectural principles for HFQ/CRC-mediated regulation of gene expression. hfq-crc-amie 2:4:2 complex
Analyse Architectural principles for HFQ/CRC-mediated regulation of gene expression.… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6O1M
- Type
- protein + RNA
- Length
- 1,877 residues
- Chains
- 18
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Catabolite repression control protein; RNA-binding protein hfq; RNA (5'…
- EC
- 3.1.11.2
- UniProt
- Q51380, Q9HUM0
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 7 distinct chains · 21% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, R, S | Catabolite repression control protein (EC 3.1.11.2) | protein | 262 | 25% helix, 24% strand | Q51380 |
| C, K | RNA-binding protein hfq | protein | 65 | 20% helix, 43% strand | Q9HUM0 |
| D, E, H, I, M | RNA-binding protein hfq | protein | 67 | 19% helix, 43% strand | Q9HUM0 |
| F, J | RNA-binding protein hfq | protein | 65 | 20% helix, 43% strand | Q9HUM0 |
| G, N | RNA-binding protein hfq | protein | 66 | 15% helix, 44% strand | Q9HUM0 |
| L | RNA-binding protein hfq | protein | 66 | 15% helix, 47% strand | Q9HUM0 |
| O, P | RNA (5'- R(*AP*AP*AP*AP*AP*UP*AP*AP*CP*AP*AP*CP*AP*AP*GP*AP*GP*G)-3') | rna | 18 | — | — |
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 812 | 0.81 | 0.84 | 78 | empty |
| 2 | 594 | 0.76 | 0.83 | 48 | empty |
| 3 | 772 | 0.74 | 0.79 | 60 | empty |
| 4 | 729 | 0.74 | 0.80 | 48 | empty |
| 5 | 854 | 0.73 | 0.78 | 60 | empty |
Interfaces
48 interfaces between chains.
- D–E · 855 Ų buried · 12 hydrogen bonds · protein-protein
- F–H · 832 Ų buried · 9 hydrogen bonds · protein-protein
- I–N · 822 Ų buried · 10 hydrogen bonds · protein-protein
- C–G · 813 Ų buried · 11 hydrogen bonds · protein-protein
- L–M · 807 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 6O1M · Architectural principles for Hfq/Crc-mediated regulation of gene expression. Hfq-Crc-amiE… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q51380
- Every structure of UniProt Q9HUM0
- Elsewhere: RCSB PDB 6O1M · PDBe 6O1M · UniProt Q51380 · UniProt Q9HUM0
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