Research workbench
Architectural principles for HFQ/CRC-mediated regulation of gene expression. hfq-crc-amie 2:2:2 complex (core complex)
Analyse Architectural principles for HFQ/CRC-mediated regulation of gene expression.… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6O1K
- Type
- protein + RNA
- Length
- 1,353 residues
- Chains
- 16
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Catabolite repression control protein; RNA-binding protein hfq; RNA (5'…
- EC
- 3.1.11.2
- UniProt
- Q51380, Q9HUM0
- Pockets
- 17 · best druggability 0.80
Structure
electron microscopy · 7 distinct chains · 21% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Catabolite repression control protein (EC 3.1.11.2) | protein | 262 | 24% helix, 24% strand | Q51380 |
| C, K | RNA-binding protein hfq | protein | 65 | 20% helix, 46% strand | Q9HUM0 |
| D, E, H, I, M | RNA-binding protein hfq | protein | 67 | 19% helix, 45% strand | Q9HUM0 |
| F, J | RNA-binding protein hfq | protein | 65 | 20% helix, 42% strand | Q9HUM0 |
| G, N | RNA-binding protein hfq | protein | 66 | 20% helix, 33% strand | Q9HUM0 |
| L | RNA-binding protein hfq | protein | 66 | 15% helix, 47% strand | Q9HUM0 |
| O, P | RNA (5'- R(*AP*AP*AP*AP*AP*UP*AP*AP*CP*AP*AP*CP*AP*AP*GP*AP*GP*G)-3') | rna | 18 | — | — |
Pockets
17 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 736 | 0.80 | 0.84 | 75 | empty |
| 2 | 699 | 0.76 | 0.81 | 60 | empty |
| 3 | 726 | 0.75 | 0.80 | 43 | empty |
| 4 | 287 | 0.72 | 0.86 | 39 | empty |
| 5 | 394 | 0.70 | 0.82 | 48 | empty |
Interfaces
37 interfaces between chains.
- I–N · 825 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 809 Ų buried · 10 hydrogen bonds · protein-protein
- D–E · 809 Ų buried · 10 hydrogen bonds · protein-protein
- M–N · 807 Ų buried · 8 hydrogen bonds · protein-protein
- L–M · 806 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 6O1K · Architectural principles for Hfq/Crc-mediated regulation of gene expression. Hfq-Crc-amiE… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q51380
- Every structure of UniProt Q9HUM0
- Elsewhere: RCSB PDB 6O1K · PDBe 6O1K · UniProt Q51380 · UniProt Q9HUM0
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