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Rorgamma ligand binding domain

Analyse Rorgamma ligand binding domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6NWS
Type: protein
Length: 259 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nuclear receptor ror-gamma
UniProt: P51449
Ligands: L77
Pockets: 3 · best druggability 0.83

Structure

x-ray diffraction · 1 distinct chain · 73% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nuclear receptor ror-gamma	protein	259	73% helix, 4% strand	P51449

Ligands and binding sites

L77 · 2-chloro-6-fluoro-N-(1-{[3-(trifluoromethyl) phenyl]sulfonyl}-2,3-dihydro-1H-indol-6-yl)benzamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	376	0.83	0.91	39	L77
2	74	0.40	0.79	14	empty
3	94	0.35	0.74	16	empty

Compared structures

6NWS · RORgamma Ligand Binding Domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P51449
Elsewhere: RCSB PDB 6NWS · PDBe 6NWS · UniProt P51449

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