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Chimeric germline Fab 7G12-apo

Analyse Chimeric germline Fab 7G12-apo in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1NGZ
Type: protein
Length: 433 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Germline metal chelatase catalytic antibody, light chain; Germline metal chelatase…
UniProt: Q58EU4
Pockets: 5 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Germline metal chelatase catalytic antibody, light chain	protein	213	6% helix, 50% strand	Q58EU4
B	Germline metal chelatase catalytic antibody, heavy chain	protein	220	8% helix, 48% strand	—

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	340	0.60	0.78	49	empty
2	314	0.55	0.75	42	empty
3	63	0.54	0.88	24	empty
4	92	0.37	0.76	18	empty
5	51	0.27	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 1877 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1NGZ · Chimeric Germline Fab 7g12-apo · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q58EU4
Elsewhere: RCSB PDB 1NGZ · PDBe 1NGZ · UniProt Q58EU4

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