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Crystal structure of TSN15 in apo form

Analyse Crystal structure of TSN15 in apo form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6NOI
Type: protein
Length: 412 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TSN15
Ligands: PO4
Pockets: 6 · best druggability 0.77

Structure

x-ray diffraction · 2 distinct chains · 18% helix, 43% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TSN15	protein	208	18% helix, 43% strand	—
B	TSN15	protein	204	18% helix, 44% strand	—

Ligands and binding sites

PO4 · Phosphate ion · ion · 2 copies · chains A, B
PGE · Triethylene glycol · additive · chains A
PEG · Di(hydroxyethyl)ether · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	300	0.77	0.89	36	PGE
2	337	0.77	0.87	35	empty
3	346	0.54	0.74	41	empty
4	74	0.40	0.79	26	PO4
5	66	0.34	0.76	14	empty

Interfaces

1 interface between chains.

A–B · 1874 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 7 modified (engineered).

Compared structures

6NOI · Crystal structure of Tsn15 in apo form · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6NOI · PDBe 6NOI

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