Research workbench
Crystal structure of fbf-2 repeat 5 mutant (C363S, R364Y, Q367S) in complex with 8-nt RNA
Analyse Crystal structure of fbf-2 repeat 5 mutant (C363S, R364Y, Q367S) in complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6NOH
- Type
- protein + RNA
- Length
- 409 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fem-3 mRNA-binding factor 2; RNA (5'-R(*UP*GP*UP*AP*AP*AP*UP*A)-3')
- UniProt
- Q09312
- Pockets
- 1 · best druggability 0.35
Structure
x-ray diffraction · 2 distinct chains · 72% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fem-3 mRNA-binding factor 2 | protein | 402 | 72% helix, 1% strand | Q09312 |
| B | RNA (5'-R(*UP*GP*UP*AP*AP*AP*UP*A)-3') | rna | 7 | — | — |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 13 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 60 | 0.35 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1247 Ų buried · 42 hydrogen bonds · protein-nucleic
Compared structures
- 6NOH · Crystal structure of FBF-2 repeat 5 mutant (C363S, R364Y, Q367S) in complex with 8-nt RNA · the same entry in another collection · chain A against A, TM-score 1.00
- Q09312 · AlphaFold monomer V2.0 prediction for fem-3 mRNA-binding factor 2 (Q09312) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q09312
- Elsewhere: RCSB PDB 6NOH · PDBe 6NOH · UniProt Q09312
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