Crystal structure of mutant B1 immunoglobulin-binding domain of streptococcal protein G (T16F, T18A, V21E, T25L, K28Y, V29I, K31R, Q32H, Y33L, N35K, D36H, N37Q)

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 43% strand (DSSP).

Ligands and binding sites

• ZN · Zinc ion · metal · 6 copies · chains A, B, C, D
• CL · Chloride ion · ion · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

4 interfaces between chains.

• A–C · 494 Ų buried · 13 hydrogen bonds · protein-protein
• B–D · 492 Ų buried · 13 hydrogen bonds · protein-protein
• A–D · 350 Ų buried · 9 hydrogen bonds · protein-protein
• A–B · 74 Ų buried · 1 hydrogen bond · protein-protein

Compared structures

• 6NL6 · Crystal structure of mutant B1 immunoglobulin-binding domain of Streptococcal Protein G… · the same entry in another collection · chain A against A, TM-score 1.00
• P19909 · AlphaFold monomer V2.0 prediction for immunoglobulin G-binding protein G (P19909) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P19909
• Elsewhere: RCSB PDB 6NL6 · PDBe 6NL6 · UniProt P19909