Research workbench
Crystal structure of a human anti-zikv-denv neutralizing antibody MZ24 isolated following zpiv vaccination
Analyse Crystal structure of a human anti-zikv-denv neutralizing antibody MZ24 isolated… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6NIS
- Type
- protein
- Length
- 439 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- MZ24 antibody heavy chain; MZ24 antibody light chain
- Ligands
- CL
- Pockets
- 6 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| H | MZ24 antibody heavy chain | protein | 223 | 4% helix, 55% strand | — |
| L | MZ24 antibody light chain | protein | 216 | 6% helix, 49% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 357 | 0.58 | 0.76 | 51 | CL |
| 2 | 131 | 0.45 | 0.77 | 25 | CL |
| 3 | 71 | 0.44 | 0.82 | 18 | empty |
| 4 | 90 | 0.43 | 0.79 | 19 | empty |
| 5 | 59 | 0.36 | 0.79 | 18 | empty |
Interfaces
1 interface between chains.
- H–L · 2046 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6NIS · Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ24 isolated following… · the same entry in another collection · chain H against H, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6NIS · PDBe 6NIS
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