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Crystal structure of human CD160 V58M mutant

Analyse Crystal structure of human CD160 V58M mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6NGG
Type: protein
Length: 218 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CD160 antigen
UniProt: O95971
Pockets: 2 · best druggability 0.41

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	CD160 antigen	protein	116	5% helix, 51% strand	O95971
B	CD160 antigen	protein	102	6% helix, 59% strand	O95971

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	72	0.41	0.80	19	empty
2	65	0.34	0.77	19	empty

Interfaces

1 interface between chains.

A–B · 889 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6NGG · Crystal structure of human CD160 V58M mutant · the same entry in another collection · chain A against A, TM-score 1.00
O95971 · AlphaFold monomer V2.0 prediction for CD160 antigen (O95971) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95971
Elsewhere: RCSB PDB 6NGG · PDBe 6NGG · UniProt O95971

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