Research workbench
Apo-BDBV223 Fab
Analyse Apo-BDBV223 Fab in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6N7U
- Type
- protein
- Length
- 417 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- BDBV223 antibody heavy chain; BDBV223 antibody light chain
- Pockets
- 4 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | BDBV223 antibody heavy chain | protein | 203 | 6% helix, 50% strand | — |
| B | BDBV223 antibody light chain | protein | 214 | 6% helix, 53% strand | — |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 359 | 0.57 | 0.75 | 49 | empty |
| 2 | 134 | 0.49 | 0.78 | 29 | empty |
| 3 | 96 | 0.38 | 0.76 | 18 | empty |
| 4 | 98 | 0.35 | 0.74 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 1795 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6N7U · apo-BDBV223 Fab · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6N7U · PDBe 6N7U
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