Research workbench
Crystal structure of TDP1 catalytic domain in complex with compound XZ530
Analyse Crystal structure of TDP1 catalytic domain in complex with compound XZ530 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MZ0
- Type
- protein
- Length
- 875 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosyl-DNA phosphodiesterase 1
- EC
- 3.1.4.-
- UniProt
- Q9NUW8
- Ligands
- K7A
- Pockets
- 7 · best druggability 0.78
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosyl-DNA phosphodiesterase 1 (EC 3.1.4.-) | protein | 437 | 27% helix, 24% strand | Q9NUW8 |
| B | Tyrosyl-DNA phosphodiesterase 1 (EC 3.1.4.-) | protein | 438 | 27% helix, 24% strand | Q9NUW8 |
Ligands and binding sites
- K7A · 5-hydroxypyrazine-2,3-dicarboxylic acid · ligand · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 944 | 0.78 | 0.80 | 92 | empty |
| 2 | 251 | 0.59 | 0.79 | 45 | empty |
| 3 | 268 | 0.55 | 0.76 | 32 | K7A |
| 4 | 236 | 0.52 | 0.76 | 32 | K7A |
| 5 | 72 | 0.39 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 633 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 6MZ0 · Crystal structure of Tdp1 catalytic domain in complex with compound XZ530 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NUW8
- Elsewhere: RCSB PDB 6MZ0 · PDBe 6MZ0 · UniProt Q9NUW8
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