Research workbench
Mouse gamma S crystallin L16 octamer
Analyse Mouse gamma S crystallin L16 octamer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MYG
- Type
- protein
- Length
- 699 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-crystallin S
- UniProt
- O35486
- Pockets
- 7 · best druggability 0.77
Structure
x-ray diffraction · 4 distinct chains · 6% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Gamma-crystallin S | protein | 174 | 7% helix, 42% strand | O35486 |
| A | Gamma-crystallin S | protein | 177 | 8% helix, 40% strand | O35486 |
| C | Gamma-crystallin S | protein | 176 | 5% helix, 47% strand | O35486 |
| D | Gamma-crystallin S | protein | 172 | 5% helix, 36% strand | O35486 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 879 | 0.77 | 0.81 | 98 | empty |
| 2 | 484 | 0.68 | 0.79 | 58 | empty |
| 3 | 332 | 0.66 | 0.81 | 32 | empty |
| 4 | 180 | 0.59 | 0.82 | 27 | empty |
| 5 | 95 | 0.36 | 0.74 | 17 | empty |
Interfaces
5 interfaces between chains.
- C–D · 1214 Ų buried · 9 hydrogen bonds · protein-protein
- B–A · 1093 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 386 Ų buried · 1 hydrogen bond · protein-protein
- B–D · 360 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 348 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O35486
- Elsewhere: RCSB PDB 6MYG · PDBe 6MYG · UniProt O35486
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