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The PRP8 intein of cryptococcus neoformans

Analyse The PRP8 intein of cryptococcus neoformans in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6MX6
Type: protein
Length: 858 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pre-mRNA-processing-splicing factor 8
UniProt: J9VI50
Pockets: 5 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 9% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Pre-mRNA-processing-splicing factor 8	protein	143	9% helix, 53% strand	J9VI50

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	853	0.84	0.86	128	empty
2	356	0.77	0.87	59	empty
3	172	0.51	0.78	34	empty
4	178	0.45	0.75	28	empty
5	155	0.43	0.75	22	empty

Interfaces

12 interfaces between chains.

D–F · 628 Å² buried · 8 hydrogen bonds · protein-protein
A–B · 580 Å² buried · 4 hydrogen bonds · protein-protein
C–E · 579 Å² buried · 9 hydrogen bonds · protein-protein
B–C · 485 Å² buried · 9 hydrogen bonds · protein-protein
D–E · 480 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

6MX6 · The Prp8 intein of Cryptococcus neoformans · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt J9VI50
Elsewhere: RCSB PDB 6MX6 · PDBe 6MX6 · UniProt J9VI50

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