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The PRP8 intein of cryptococcus gattii

Analyse The PRP8 intein of cryptococcus gattii in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6MWY
Type: protein
Length: 420 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pre-mRNA-processing-splicing factor 8
UniProt: A0A095EAP2
Pockets: 5 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 9% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Pre-mRNA-processing-splicing factor 8	protein	140	9% helix, 54% strand	A0A095EAP2

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	417	0.68	0.81	52	empty
2	116	0.43	0.78	15	empty
3	96	0.39	0.77	16	empty
4	94	0.34	0.74	15	empty
5	93	0.34	0.74	19	empty

Interfaces

3 interfaces between chains.

A–B · 453 Å² buried · 0 hydrogen bonds · protein-protein
A–C · 248 Å² buried · 6 hydrogen bonds · protein-protein
B–C · 25 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 modified (engineered).

Compared structures

6MWY · The Prp8 intein of Cryptococcus gattii · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A095EAP2
Elsewhere: RCSB PDB 6MWY · PDBe 6MWY · UniProt A0A095EAP2

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