Research workbench
Crystal structure of T. pallidum leucine rich repeat protein (tplrr)
Analyse Crystal structure of T. pallidum leucine rich repeat protein (tplrr) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MLX
- Type
- protein
- Length
- 852 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leucine-rich repeat protein tplrr
- UniProt
- O06686
- Pockets
- 6 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 6% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leucine-rich repeat protein tplrr | protein | 212 | 6% helix, 24% strand | O06686 |
| B, D | Leucine-rich repeat protein tplrr | protein | 213 | 6% helix, 23% strand | O06686 |
| C | Leucine-rich repeat protein tplrr | protein | 214 | 6% helix, 23% strand | O06686 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 567 | 0.69 | 0.78 | 48 | empty |
| 2 | 573 | 0.64 | 0.75 | 62 | empty |
| 3 | 133 | 0.49 | 0.79 | 24 | empty |
| 4 | 158 | 0.42 | 0.74 | 20 | empty |
| 5 | 156 | 0.41 | 0.74 | 32 | empty |
Interfaces
5 interfaces between chains.
- C–D · 559 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 453 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 448 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 414 Ų buried · 5 hydrogen bonds · protein-protein
- A–D · 145 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6MLX · Crystal structure of T. pallidum Leucine Rich Repeat protein (TpLRR) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O06686
- Elsewhere: RCSB PDB 6MLX · PDBe 6MLX · UniProt O06686
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