Research workbench
Cryo-EM structure of human parainfluenza virus type 3 (HPIV3) in complex with antibody PIA174
Analyse Cryo-EM structure of human parainfluenza virus type 3 (HPIV3) in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MJZ
- Type
- protein
- Length
- 1,477 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fusion glycoprotein F0; PIA174 Fab heavy chain; PIA174 Fab light chain
- UniProt
- A0A059QA82
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 5 distinct chains · 26% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Fusion glycoprotein F0 | protein | 426 | 30% helix, 16% strand | A0A059QA82 |
| B | Fusion glycoprotein F0 | protein | 408 | 34% helix, 17% strand | A0A059QA82 |
| C | Fusion glycoprotein F0 | protein | 415 | 29% helix, 15% strand | A0A059QA82 |
| H | PIA174 Fab heavy chain | protein | 120 | 3% helix, 40% strand | — |
| L | PIA174 Fab light chain | protein | 108 | 0% helix, 31% strand | — |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 891 | 0.87 | 0.89 | 111 | empty |
| 2 | 799 | 0.79 | 0.82 | 96 | empty |
| 3 | 990 | 0.79 | 0.80 | 124 | empty |
| 4 | 273 | 0.76 | 0.88 | 32 | empty |
| 5 | 113 | 0.74 | 0.94 | 29 | empty |
Interfaces
9 interfaces between chains.
- A–B · 1682 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 1616 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 1493 Ų buried · 8 hydrogen bonds · protein-protein
- H–L · 989 Ų buried · 10 hydrogen bonds · protein-protein
- C–L · 335 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
- 6MJZ · Cryo-EM structure of Human Parainfluenza Virus Type 3 (hPIV3) in complex with antibody… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A059QA82
- Elsewhere: RCSB PDB 6MJZ · PDBe 6MJZ · UniProt A0A059QA82
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.