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Crystal structure of an organic hydroperoxide resistance protein osmc, predicted redox protein, regulator of sulfide bond formation from legionella pneumophila
Analyse Crystal structure of an organic hydroperoxide resistance protein osmc… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6MJN
- Type
- protein
- Length
- 554 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Organic hydroperoxide resistance protein
- UniProt
- A0A2S6F4M7
- Ligands
- CL
- Pockets
- 3 · best druggability 0.83
Structure
x-ray diffraction · 4 distinct chains · 34% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Organic hydroperoxide resistance protein | protein | 138 | 33% helix, 35% strand | A0A2S6F4M7 |
| B | Organic hydroperoxide resistance protein | protein | 140 | 34% helix, 34% strand | A0A2S6F4M7 |
| C | Organic hydroperoxide resistance protein | protein | 137 | 36% helix, 33% strand | A0A2S6F4M7 |
| D | Organic hydroperoxide resistance protein | protein | 139 | 33% helix, 31% strand | A0A2S6F4M7 |
Ligands and binding sites
- CL · Chloride ion · ion · 3 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 760 | 0.83 | 0.86 | 82 | empty |
| 2 | 195 | 0.65 | 0.84 | 24 | empty |
| 3 | 160 | 0.64 | 0.85 | 22 | empty |
Interfaces
6 interfaces between chains.
- C–D · 2876 Ų buried · 53 hydrogen bonds · protein-protein
- A–B · 2862 Ų buried · 50 hydrogen bonds · protein-protein
- B–D · 216 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 212 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 171 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6MJN · Crystal structure of an organic hydroperoxide resistance protein OsmC, predicted redox… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A2S6F4M7
- Elsewhere: RCSB PDB 6MJN · PDBe 6MJN · UniProt A0A2S6F4M7 · AlphaFold DB A0A2S6F4M7
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